We will deal intensively with special issues of toxicology and thus develop a deeper understanding of toxicological assessments of chemicals, starting from exposure and dose-response relationships, through standardised test procedures to in vitro and in silico methods and alternative assessment strategies.
For this purpose, we will deal with application examples from the following topics:
-external and internal exposure,
-dose-response relationships,
-standardised test methods (animal tests according to OECD guidelines)
-classical risk assessment of chemicals and food ingredients/contaminants
-in-vitro tests (e.g. genotoxicity, mutagenicity),
-in silico methods (e.g. adverse outcome pathway (AOP) skin sensitisation, (quantitative) structure-activity relationships ((Q)SAR), threshold of toxicological concern (TTC)),
-alternative assessment strategies (e.g. read across, AOP, Integrated Approach to testing and assessment (IATA)).
- Dozent/in: Monika Batke